An overview of sphingolipid metabolism from synthesis to breakdown gault cr1 obeid lm hannun ya of this basic structure is what gives rise to the vast family of sphingolipids that play significant roles in membrane biology and provide many bioactive metabolites that regulate cell function despite the diversity of structure and . This book presents an overview of sphingolipids biology synthesis and functions the topics analyzed in this book cover a broad spectrum of functions played by sphingolipids including the role of sphingomyelin in the regulation of membrane physical state tricyclic antidepressants as modulators of sphingolipid turnover and cell sensitivity . Sphingolipids are a class of lipids with a polar head group and two nonpolar tails the core of a sphingolipid is an amino alcohol called sphingosine complex sphingolipids located in the plasma membrane of animal cells especially nerve cells have a structural function and are believed to protect the cell surface from harmful environmental factors
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